GUANGZHOU, China (Reuters) - The coronavirus outbreak is hitting a peak in China this month and may be over by April, the government’s senior medical adviser said on Tuesday, in the latest assessment of an epidemic that has rattled the world. In an interview with Reuters, Zhong Nanshan, an 83-year-old epidemiologist who won fame for combating the SARS epidemic in 2003, shed tears about the doctor Li Wenliang who died last week after being reprimanded for raising the alarm. But Zhong was optimistic the new outbreak would soon slow, with the number of new cases already declining in some places. The peak should come in middle or late February, followed by a plateau and decrease, Zhong said, basing the forecast on mathematical modelling, recent events and government action. “I hope this outbreak or this event may be over

The incubation period for the deadly coronavirus could be as long as 24 days, according to a study led by Zhong Nanshan, an expert on respiratory infections and the head of the health commission team investigating the outbreak. The incubation period is the time it takes between being exposed to a virus and symptoms appearing. Previously, medical experts said that coronavirus, also known as corona, had an incubation period of between two and 14 days. But the study, published on Sunday, revealed that the incubation period is between three and 24 days, meaning that more people may have coronavirus without visible symptoms than previously thought. The lethal virus has killed more than 900 people and infected more than 40,600 people globally. The death toll for the coronavirus has surpassed the 774 fatalities from the outbreak of severe acute

The World Health Organization’s director-general cautioned Saturday that transmission of the new coronavirus outside of China may increase and countries should prepare for that possibility. “It’s slow now, but it may accelerate,” Tedros Adhanom Ghebreyesus said during a press conference in Geneva. “So while it’s still slow there is a window of opportunity that we should use to the maximum in order to have a better outcome, and further decrease the progress and stop it.” Tedros’s warning came after health authorities in Singapore announced they had diagnosed the infection in a man with no travel history to China and no known link to other cases in Singapore. Singaporean authorities suggested — but did not order — that large public events be canceled or deferred. If public events are held, temperature screening of attendees should be

Ученые из Грейфсвальда и Бохума опубликовали раньше, чем планировалось, свои исследования о новом коронавирусе из Китая. Они предполагают, что вирус 2019-nCoV может жить на разных поверхностях при комнатной температуре до 9 дней. В среднем же он выживает 4-5 дней. Об этом пишет Der Tagesspiegel. Повышенная влажность и холод могут увеличить срок жизни вируса, отмечают ученые. Как пояснил Гюнтер Кампф из института Грейфсвальд, «вирус может распространяться через соприкосновение с поверхностями: в больнице это могут быть, например, дверные ручки, звонки, тумбочки, прикроватные столики и другие предметы, которыми пользуются пациенты». «Чтобы сделать такое заключение [о том, что вирус живет до 9 дней], надо было иметь выделенный вирус (как минимум 9 дней назад), подержать его на поверхности, а потом проверить,

LONDON/BEIJING (Reuters) - Independent scientists questioned research on Friday that suggested that the outbreak of coronavirus disease spreading from China might have passed from bats to humans through the illegal traffic of pangolins. South China Agricultural University, which said it had led the research, said on its website that the “discovery will be of great significance for the prevention and control of the origin (of the new virus)”. China’s official Xinhua news agency reported that the genome sequence of the novel coronavirus strain separated from pangolins in the study was 99% identical to that from infected people. It said the research had found pangolins - the world’s only scaly mammals - to be “the most likely intermediate host.” But James Wood, head of the veterinary medicine department at Britain’s University of Cambridge, said the research was far from robust. “The evidence for the potential

Xiaoqiang Chai, Longfei Hu, Yan Zhang, Weiyu Han, Zhou Lu, Aiwu Ke, Jian Zhou, Guoming Shi, Nan Fang, Jia Fan, Jiabin Cai, Jue Fan, Fei Lan

doi: https://doi.org/10.1101/2020.02.03.931766

Abstract A newly identified coronavirus, 2019-nCoV, has been posing significant threats to public health since December 2019. ACE2, the host cell receptor for severe acute respiratory syndrome coronavirus (SARS), has recently been demonstrated in mediating 2019-nCoV infection. Interestingly, besides the respiratory system, substantial proportion of SARS and 2019-nCoV patients showed signs of various degrees of liver damage, the mechanism and implication of which have not yet been determined.

Summary Background In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. Methods In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020. Findings Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had

With the new coronavirus spreading from person to person (possibly including from people without symptoms), reaching four continents, and traveling faster than SARS, driving it out of existence is looking increasingly unlikely. It’s still possible that quarantines and travel bans will first halt the outbreak and then eradicate the microbe, and the world will never see 2019-nCoV again, as epidemiologist Dr. Mike Ryan, head of health emergencies at the World Health Organization, told STAT on Saturday. That’s what happened with SARS in 2003. Many experts, however, view that happy outcome as increasingly unlikely. “Independent self-sustaining outbreaks [of 2019-nCoV] in major cities globally could become inevitable because of substantial exportation of pre-symptomatic cases,” scientists at the University of Hong Kong concluded in a paper published in The Lancet last week. Researchers

It is still too early, and available information is still too incomplete, to be certain about many aspects of the 2019 novel coronavirus (2019-nCoV) outbreak in China. However, important elements of the management of this global health emergency—and it is an emergency of major international concern—are becoming clearer. As the outbreak accelerates, there are early lessons to be learned. The transmissibility of 2019-nCoV—or at least its geographical distribution—seems to be higher and broader than initially expected. Why? Partly this may be because of China's rapid expansion of its transport networks, especially air and high-speed rail. Wuhan is a crucial hub: linking west to Chengdu, south to Guangzhou and Shenzhen, east to Nanjing and Shanghai, and north to Beijing. With much of December a period when the outbreak went unreported and unrecognised, the population exposed to the virus is far

As China struggles to contain an epidemic caused by a new coronavirus, science is racing to develop vaccines to blunt the outbreak’s impact. Central to the effort is CEPI — the Oslo, Norway-based Coalition for Epidemic Preparedness Innovations — a global partnership created to spearhead development of vaccines in just this type of emergency. Two weeks after China announced on Jan. 7 that a new coronavirus had ignited a fast-growing outbreak of pneumonia cases in the city of Wuhan, CEPI announced funding for three efforts to develop a vaccine to protect against the virus, currently known as 2019-nCoV. A week later, it added a fourth. Just days after that, it announced major vaccine manufacturer GSK would allow its proprietary adjuvants — compounds that boost the effectiveness of vaccines — to be used in the response. But to

People showing no symptoms appear to be able to spread the novel coronavirus that has caused an outbreak in China and led world health authorities to declare a global emergency, researchers reported Thursday in the New England Journal of Medicine. If confirmed, the finding will make it much harder to contain the virus. The case described — from Germany — could help resolve one of the major unknowns about the virus, which as of Thursday night had infected nearly 9,700 people in China and killed 213. About 100 more infections have been reported in 18 other countries, but no deaths. Some viruses, including SARS, which is another coronavirus, can only be passed when a person is showing symptoms. Others, like the flu, can be spread a day or two before the onset of symptoms. If people are contagious before they become sick, they can be unknowingly spreading the virus as they go shopping or to work or to the

По итогам прошлого года отставание нашей страны в сфере науки и технологий выглядит катастрофическим Данные в трех важнейших областях за 2019 год привел в своем блоге сетевой аналитик Дмитрий Милин: Высокотехнологичный экспорт Китай: $654 млрд Германия: $210 млрд США: $156 млрд Россия: $10 млрд Научные статьи Китай: 426 165 США: 408 985 Германия: 103 122 Россия: 59 134 Международные патентные заявки США: 56 142 Китай: 53 345 Германия: 19 883 Россия: 963 Здесь непременно стоит отметить еще и вот какую деталь: на первый взгляд отставание России в количестве научных статей выглядит не таким колоссальным, как по двум другим параметрам. Однако, это совершенно не так. Вот что заметил по этому поводу аналитик Владислав Иноземцев:

https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full.pdf+html

Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishna Menon, James Gomes, Perumal Vivekanandan, Bishwajit Kundu

doi: https://doi.org/10.1101/2020.01.30.927871

Abstract

We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV

Yu Zhao, Zixian Zhao, Yujia Wang, Yueqing Zhou, Yu Ma, Wei Zuo

doi: https://doi.org/10.1101/2020.01.26.919985

Abstract

A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here

Cercetătorii din Timișoara spun că au găsit calea spre un vaccin pentru coronavirus. Acesta se administrează pe același principiu cu cel pentru gripa normală. Specialiștii în cancer de la institutul OncoGen din Timișoara au publicat un studiu despre tratarea coronavirusului. Potrivit acestuia, vaccinul ar putea fi dezvoltat printr-o tehnologie utilizată în vaccinarea personalizată folosită în oncologie. „Există două variante: să dezvolți un vaccin cu care să vaccinezi populația la nivel global și să oprești epidemia, sau să dezvolți un medicament, cum s-a întâmplat în hepatita C sau în SIDA, care să vindece pacienții care au fost deja afectați de această boală. Noi am reluat o cercetare mai veche, la care lucrăm de vreo 4 ani. Este o metodă nouă de abordare a producerii de vaccinuri în cazul infecțiilor virale. După cum știți, a apărut tehnologia de vaccinare personalizată în cancer. Acolo lucrurile sunt mult mai

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